RNA modifications as emerging therapeutic targets

ÇAYIR A.

WILEY INTERDISCIPLINARY REVIEWS-RNA, cilt.13, sa.4, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/wrna.1702
  • Dergi Adı: WILEY INTERDISCIPLINARY REVIEWS-RNA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Anahtar Kelimeler: drug discovery, m6A, RNA modifications, RNA modifying genes, GENE-EXPRESSION PROFILES, STEM-LIKE CELLS, MESSENGER-RNA, RIBOSOMAL-RNA, VALPROIC ACID, ADENOSINE-DEAMINASE, SACCHAROMYCES-CEREVISIAE, N-6-METHYLADENOSINE RNA, TRANSCRIPTOME RESPONSES, INDUCED HEPATOTOXICITY
  • Çanakkale Onsekiz Mart Üniversitesi Adresli: Evet

Özet

The field of epitranscriptome, posttranscriptional modifications to RNAs, is still growing up and has presented substantial evidences for the role of RNA modifications in diseases. In terms of new drug development, RNA modifications have a great promise for therapy. For example, more than 170 type of modifications exist in various types of RNAs. Regulatory genes and their roles in critical biological process have been identified and they are associated with several diseases. Current data, for example, identification of inhibitors targeting RNA modifications regulatory genes, strongly support the idea that RNA modifications have potential as emerging therapeutic targets. Therefore, in this review, RNA modifications and regulatory genes were comprehensively documented in terms of drug development by summarizing the findings from previous studies. It was discussed how RNA modifications or regulatory genes can be targeted by altering molecular mechanisms. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Processing > RNA Editing and Modification